منابع مشابه
Genomic imprinting: Mother maintains methylation marks
A DNA methyltransferase has been identified that plays a role in maintaining the methylation status of imprinted genes. Interestingly, although expressed in the unfertilised egg, this enzyme functions only during one round of replication in the eight-cell embryo.
متن کاملDNA methylation of methylation complex genes in relation to stress and genome-wide methylation in mother-newborn dyads.
OBJECTIVES Early life stress is known to have enduring biological effects, particularly with respect to health. Epigenetic modifications, such as DNA methylation, are a possible mechanism to mediate the biological effect of stress. We previously found correlations between maternal stress, newborn birthweight, and genome-wide measures of DNA methylation. Here we investigate ten genes related to ...
متن کاملPreventive Aids Transmission Factors from Mother to Baby
این بررسی به منظور تعیین مشخصات زنان باردار آلوده به ویروس نقص ایمنی انسان از نوع 1 (1-HIV) با احتمال انتقال 1-HIV از مادر به نوزاد انجام شده است. واحدهای مورد پژوهش شامل زنان باردار و یا بلافاصله بعد از زایمان در خطر ابتلا به HIV بودند که از سال ۱۹۸۶ تا ۱۹۹۲ در بخشهای مراقبت مادران و کودکان نیویورک بستری شده بودند. مشخصات دموگرافیک و رفتاری، ابتلاء به بیماریهای کلینیکی، نوع لنفوسیت T، غلظت ایم...
متن کاملAids-associated Retrovirus from Mother to Infant
or bisexuals, intravenous drug abusers, recipients of blood and blood products, Haitians, and the heterosexual partners of individuals in these groups.4-7 Affected infants, who account for about 1% of cases of AIDS, have usually been born to women in these at-risk groups. A smaller number of infants seem to have acquired the disease from blood transfusions.9 Where the mother has been the appare...
متن کاملPrenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother–infant pairs
A precise biological mechanism by which cadmium acts as a developmental toxicant is unknown but is suggested to include an epigenetic basis. In prior work, we analyzed CpG island methylation levels within gene promoters (n=16,421) in leukocytes collected from mothers and their infants from a pregnancy cohort in Durham County, North Carolina. The CpG methylation levels were examined in relations...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2010
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg2923